COPD Causes, Sign and Symptoms, Caussual Factors: Those Who are at Risk

Chronic obstructive pulmonary disease (COPD) is a treatable and preventable illness that is characterized by irreversible limitation of airflows. The limitation of the airflow is progressive and linked to unusual inflammation response of the lungs to harmful gases as well as particles. The diseases occur when the airway passes (bronchi or bronchioles) are obstructed by the inflammation or excessive production of phlegm. The narrowing of the airways causes continuous limitation of airflow, shortness of breath, exertion as well as air trapping. COPD causes many global deaths causes 12 million to 24 million deaths in the world and is a leading cause of death in the united states(Barnes, 201007, p.122). This paper aims to describe body changes as a result of COPD, sign and symptoms, caussual factors as well as those who are at risk of getting the disorder.

COPD is causeds by systematic inflammation the exposure to smoke, gasses, as well as dust particles, as well as dust particles causes the airways passages such as bronchi, alveolus, and bronchioles in the respiratory system to swell as shown in Figure1. According to Barnes (20071007) argues that , the inflammation of the response of the lungs is causeds by an increase in the number of macrophages, neutrophils, and T-lymphocytes (p.,112). The inflation also occurs due to increase in the concentration of cytokines, increased oxidative stress such as smoke from tobacco, dust particles and other foreign gases. The narrowing of the air pathways in the lungs reduces the airflow, increasinge shortness of breath as well as increase air trapping.

Figure 1: Systematic inflammation of airway passage (Bupa, 2018).

COPD causes abnormalities in nutrition and weight loss according to Schols (2000) argues that COPD can alter the intake of calories, intermediate metabolism, basal metabolic rates well as the composition of the body (p.p, 112). Agustí (2007) reveals that 50% of a patient suffering from severe COPD experiences loss in body weight while 10% of those suffering from the disorder also experiences weight loss (p. ,522). According to Schols (2000) reasons that, the weight loss is due to losss of in the mass of the skeletal muscles as well as fat mass. Schols (2000) also argues that tThe loss in body composition can occur in absence of considerable loss in body weight (Schols, 2000, p. , 113). The disorder also results in increased in the basal metabolic rate due to several mechanisms such as increased breathing common among COPD patients (Schols, 2000, p.113). The rise in basal metabolic may eventually lead to weight loss.

The disorder also results in skeletal muscle dysfunctional according to Agustí (2007) argues that , COPD causes both functional and specific atomic changes in the muscles which reduced patients’ ability to exercise as well as reduce the quality of life (p. ,523). COPD can cause changes atrophy and fiber-type composition of muscles. The disorder can also lead to loss of muscles endurance, enzymatic activities as well as strength (Agustí, 2007, p.523). Agustí (2007) argues that patient with COPD have increased circulation of cytokines which result in protein inactivation and degradation (p.,523). The degradation and inactivation of protein lead to muscles dysfunction. COPD also increase the risk of cardiovascular disorders. According to Duncan (2016) reasons that Sin and Man (2003) COPD result into abnormal endothelial functions in both renal and pulmonary circulation. The increaseds risk is associated with increased smoking common among COPD patients (p.363). Agustí (2007) also argue that persistent systemic inflammation in the airway passages could be associated with the increased cardiovascular diseases (p.524).

Productive cough experienced in the morning with white or colourless sputum is a major sign and symptom of COPD the first sign and symptom of COPD include a productive cough in the morning hours productive with while or colorless sputum. Such TheAThe cough is normally persistent does not go away. Patients also experience The disease is also characterized by shortness of breath or dyspneadyspnoea. The shortness of breath occurs in early stages the symptom may take place infrequently with exertion and may eventually advance to breathlessness when the patient is handling minor task such as walking to the bathroom or standing up (Barnett, 2006, p.15).. The shortness of breath may also occur in the form of wheezing.

Patients may also experience unintended weight loss. Such weight loss occurs in later stages due to low intake of calories and loss of mass of skeletal muscles.

The high number of COPD (73%) in developed nations is mainly caused by increased tobacco smoking exposure to fumes from burning fuels during heating and cooking in poorly ventilated rooms plays a significant role in causing COPD in developing states. The genetic disorder such as deficiency of alpha-1 anti-trypsin (AAT) deficiency also causes COPD. Under the deficiency of AAT, the lungs have less protein to protect them from damage, thus resulting into COPD.

COPD is associated with several risk factors long-term exposure to tobacco smoke or smoking is a major risk factor for COPD. The risk of getting COPD increases with years of smoking tobaccotobacco (Barnett, 2006, p.8). (Berry and Wise, 2010, p.377). Individual exposed to marijuana smoke, cigar, secondhandsecond-hand smoke, as well as pipe smoke may also be at risk of the disease (Mayo Clinic, 2018). An asthmatic individual who smokes hasve a high risk of getting COPD. The combination of asthma, obstruction in the air way passage as well as smoking lead increases the risk of COPD. Long-term exposure to dust, chemical fumes, vaporvapour at work place increases inflammation of lungs and risk of COPD(Berry and Wise, 2010, p.377). GGenetic disorders such as alpha-1-antitrypsin deficiency can also trigger COPD (Mayo Clinic, 2018). COPD can also be trigger by constant exposure to fumes from burning fuels from the poorly ventilated house.

COPD is a non-reversible condition of the lungs caused by the reduction in the size of airways passage the limitation of airflow due to narrowing of the bronchioles and alveolus may cause cardiovascular disease, abnormal nutrition and weight loss, skeletal muscle dysfunction. The disorder is caused by smoking, genetics, asthma as well as secondhandsecond-hand gases. COPD risk factors include long-term smoking, exposure to dust and inflammatory chemicals as well as AAT deficiency.

References

Agustí, A., 2007. Systemic effects of chronic obstructive pulmonary disease: what we know and what we don't know (but should). Proceedings of the American Thoracic Society, 4(7), pp.522-525.

Barnes, P.J., 2007. Chronic obstructive pulmonary disease: a growing but neglected global epidemic. PLoS medicine, 4(5), p.ep. e112.

Barnett, M. (2006). Chronic Obstructive Pulmonary Disease in Primary Care. Hoboken, Wiley

Berry, C.E., and Wise, R.A., 2010. Mortality in COPD: causes, risk factors, and prevention. COPD: Journal of Chronic Obstructive Pulmonary Disease, 7(5), pp.375-382.

Bupa. (2018). Chronic obstructive pulmonary disease (COPD). [online] Mayo clinic. Available at: https://www.bupa.co.uk/health-information/directory/c/copd [Accessed 09 May. 2018].

Duncan, D., 2016. Chronic obstructive pulmonary disease: an overview. British Journal of Nursing, 25(7), pp.360-366.

Mayo Clinic. (2018). Chronic Obstructive Pulmonary Disease. [online] Mayo clinic. Available at: https://www.mayoclinic.org/diseases-conditions/copd/symptoms-causes/syc-2035367 [Accessed 09 May. 2018].

Schols, A.M.W.J., 2000. Nutrition in chronic obstructive pulmonary disease. Current opinion in pulmonary medicine, 6(2), pp.110-115.

Agustí, A., 2007. Systemic effects of chronic obstructive pulmonary disease: what we know and what we don't know (but should). Proceedings of the American Thoracic Society, 4(7), pp.522-525.

Barnes, P.J., 201007. Chronic obstructive pulmonary disease: a growing but neglected global epidemic. PLoS medicine, 4(5), p.ep. e112.

Berry, C.E., and Wise, R.A., 2010. Mortality in COPD: causes, risk factors, and prevention. COPD: Journal of Chronic Obstructive Pulmonary Disease, 7(5), pp.375-382.

Bupa. (2018). Chronic obstructive pulmonary disease (COPD). [online] Mayo clinic. Available at: https://www.bupa.co.uk/health-information/directory/c/copd [Accessed 09 May. 2018].

Mayo Clinic. (2018). Chronic Obstructive Pulmonary Disease. [online] Mayo clinic. Available at: https://www.mayoclinic.org/diseases-conditions/copd/symptoms-causes/syc-2035367 [Accessed 09 May. 2018].

Schols, A.M.W.J., 2000. Nutrition in chronic obstructive pulmonary disease. Current opinion in pulmonary medicine, 6(2), pp.110-115.

Sin, D.D. and Man, S.P., 2003. Why are patients with chronic obstructive pulmonary disease at increased risk of cardiovascular diseases: The potential role of systemic inflammation in chronic obstructive pulmonary disease. Circulation, 107(11), pp.1514-1519.

Agustí, A., 2007. Systemic effects of chronic obstructive pulmonary disease: what we know and what we don't know (but should). Proceedings of the American Thoracic Society, 4(7), pp.522-525.

Bupa. (2018). Chronic obstructive pulmonary disease (COPD). [online] Mayo clinic. Available at: https://www.bupa.co.uk/health-information/directory/c/copd [Accessed 09 May. 2018].

Barnes, P.J., 201007. Chronic obstructive pulmonary disease: a growing but neglected global epidemic. PLoS medicine, 4(5), p.ep. e112.

Schols, A.M.W.J., 2000. Nutrition in chronic obstructive pulmonary disease. Current opinion in pulmonary medicine, 6(2), pp.110-115.

Sin, D.D. and Man, S.P., 2003. Why are patients with chronic obstructive pulmonary disease at increased risk of cardiovascular diseases: The potential role of systemic inflammation in chronic obstructive pulmonary disease. Circulation, 107(11), pp.1514-1519.

Mayo Clinic. (2018). Chronic Obstructive Pulmonary Disease. [online] Mayo clinic. Available at: https://www.mayoclinic.org/diseases-conditions/copd/symptoms-causes/syc-2035367 [Accessed 09 May. 2018].

Berry, C.E., and Wise, R.A., 2010. Mortality in COPD: causes, risk factors, and prevention. COPD: Journal of Chronic Obstructive Pulmonary Disease, 7(5), pp.375-382.